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The Resource PKA as an upstream kinase for LKB1/STRAD/MO25, by Seth T. Herway

PKA as an upstream kinase for LKB1/STRAD/MO25, by Seth T. Herway

Label
PKA as an upstream kinase for LKB1/STRAD/MO25
Title
PKA as an upstream kinase for LKB1/STRAD/MO25
Statement of responsibility
by Seth T. Herway
Creator
Subject
Genre
Language
eng
Summary
The LKB1/STRAD/MO25 complex (LSMK) has been identified as the major upstream kinase for AMP-activated protein kinase (AMPK). PKA phosphorylates LKB1 at the Ser428 residue in humans and Ser431 residue in mice. We investigated PKA as an upstream kinase for LSMK. LKB1 that had been incubated with PKA prior to incubation with AMPK experienced up to a 51% increase in AMPK Kinase activity compared to LKB1 alone (p < 0.05). When blocked with a PKA Inhibitor, the kinase effect of PKA on LKB1 was eliminated. Rat epitrochlearis muscle tissue incubated with epinephrine experienced no increase in AMPK activity compared with controls indicating that epinephrine does not cause AMPK activity in this type of tissue. In conclusion, phosphorylation by PKA can increase the AMPKK activity of LKB1-STRAD-MO25 in vitro. Because LKB1 has been found to be constitutively active, it is postulated that phosphorylation by PKA may act to enhance LKB1-AMPK interaction and thus achieve its effect
Cataloging source
UPB
Degree
M.S.
Dissertation year
2006
Granting institution
Brigham Young University. Dept. of Physiology and Developmental Biology
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • bibliography
  • theses
Label
PKA as an upstream kinase for LKB1/STRAD/MO25, by Seth T. Herway
Link
http://hdl.lib.byu.edu/1877/etd1404
Instantiates
Publication
Bibliography note
Includes bibliographical references (p. 33-37)
Carrier category
volume
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Dimensions
cm.
Extent
viii, 49 p.
Media category
unmediated
Media MARC source
rdamedia
Other physical details
ill.
System control number
  • UtOrBLW
  • (OCoLC)ocn376833484
Label
PKA as an upstream kinase for LKB1/STRAD/MO25, by Seth T. Herway
Link
http://hdl.lib.byu.edu/1877/etd1404
Publication
Bibliography note
Includes bibliographical references (p. 33-37)
Carrier category
volume
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Dimensions
cm.
Extent
viii, 49 p.
Media category
unmediated
Media MARC source
rdamedia
Other physical details
ill.
System control number
  • UtOrBLW
  • (OCoLC)ocn376833484

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