The Resource The effects of aging on skeletal muscle AMPK activation and an analysis of chronic AICAR treatment on the aging phenotype, Shalene E. Hardman

The effects of aging on skeletal muscle AMPK activation and an analysis of chronic AICAR treatment on the aging phenotype, Shalene E. Hardman

Label
The effects of aging on skeletal muscle AMPK activation and an analysis of chronic AICAR treatment on the aging phenotype
Title
The effects of aging on skeletal muscle AMPK activation and an analysis of chronic AICAR treatment on the aging phenotype
Statement of responsibility
Shalene E. Hardman
Creator
Author
Subject
Language
eng
Summary
  • AMP-activated protein kinase (AMPK), a metabolic regulator, acts in opposition to many of the effects of aging and may provide insights into the development of sarcopenia. However, the effect of aging on AMPK activation is unclear. The purpose of this dissertation was to: 1) clarify the controversy concerning the activation of AMPK in response to endurance-like exercise in aged skeletal muscle; 2) address mechanisms for the age-associated alterations in AMPK activation; and 3) address the known benefits of chronic AICAR treatment in aged skeletal muscle
  • First, to clarify the effect of age on AMPK activation, young adult (YA) (8mo.) and old (O) (30 mo.) male Fischer344 x Brown Norway F1 hybrid rats received an in situ bout of endurance-type contractions produced via electrical stimulation of the sciatic nerve (STIM). AMPK activation was attenuated in aging muscle as demonstrated by decreased AMPKα phosphorylation and AMPKα2 protein content and activity in O vs. YA muscle after STIM. In contrast, AMPKα1 content was greater in O vs YA muscle, and α1 activity increased with STIM in O but not YA muscles
  • Second, the effect of age on the AMPK heterotrimer composition and nuclear localization was assessed as mechanisms for the altered AMK activation. The AMPK heterotrimer composition was altered in aging skeletal muscle with lower AMPKγ3 with AMPKα1 and α2. Furthermore, activation of AMPK is known to increase translocation of AMPK to the nucleus in YA muscle; however, translocation of phosphorylated AMPK, AMPKα2, and AMPKγ3 were impaired in the aging rat muscle after STIM
Cataloging source
UPB
Degree
Doctor of Philosophy
Dissertation year
2014
Granting institution
Brigham Young University. Department of Physiology and Developmental Biology
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • bibliography
  • theses
Label
The effects of aging on skeletal muscle AMPK activation and an analysis of chronic AICAR treatment on the aging phenotype, Shalene E. Hardman
Instantiates
Production
Bibliography note
Includes bibliographical references (pages 95-110)
Carrier category
volume
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Dimensions
29 cm
Extent
x, 113 pages
Media category
unmediated
Media MARC source
rdamedia
Other physical details
illustrations (some color)
System control number
UtOrBLW
Label
The effects of aging on skeletal muscle AMPK activation and an analysis of chronic AICAR treatment on the aging phenotype, Shalene E. Hardman
Production
Bibliography note
Includes bibliographical references (pages 95-110)
Carrier category
volume
Carrier MARC source
rdacarrier
Content category
text
Content type MARC source
rdacontent
Dimensions
29 cm
Extent
x, 113 pages
Media category
unmediated
Media MARC source
rdamedia
Other physical details
illustrations (some color)
System control number
UtOrBLW

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